We Study Molecular Recognition

Signal transduction pathways represent an accurate, complex and intricate way of transporting messages between neighboring cells. The accurate recognition of soluble, extracellular ligands by complex receptor assemblies determines multiple cellular functions by triggering or inhibiting the expression of specific target genes. It is clear that any malfunction of such a delicate, tightly regulated system would result in the re-programming of many cell functions, often with tremendous, unexpected effects.

We study these communication mechanisms by focussing on molecular recognition and regulation processes in bio-medically relevant proteins. Please check the detailed research topic pages on the side menu.

In many cases, the proteins involved are multi-domain proteins, functioning as a unique protein machinery that carries out elementary regulatory functions such as activation, stabilization, localization and inhibition. Our goal is to reveal the mechanisms of tertiary and quaternary-induced activation in multi-domain proteins and multi-protein complexes that underlie these recognition and regulation processes.



 

This video (in Italian) was recorded on Nov 13th, 2017 and contains the full lectio magistralis given for the Inauguration of the University of Pavia Academic Year 2017-2018.




This interview (in English) was recorded in our lab in October 2014 to describe our research topics and methodologies. This is part of a series of videos created by the Armenise-Harvard Foundation - Website.




This interview (in Italian) was recorded in our lab in March 2014 to illustrate our approach to the University of Pavia WebTV.



We gratefully acknowledge the support received over the years by:

  • Armenise-Harvard Foundation's Career Development Award
  • Program for Young Researchers "Rita Levi-Montalcini" from MIUR
  • Italian Association for Cancer Research program "My First AIRC Grant"
  • Fondazione Cariplo's program "Bio-Medical Research performed by Young Scientists"
  • Programmi di Ricerca di Interesse Nazionale (PRIN) from the Italian Ministry of Education, University and Research (MIUR)
  • University Institute of Superior Studies, Pavia (IUSS)
  • MSCA-IF COTETHERS project, funded by the EU H2020 program MSCA-IF COTETHERS project, funded by the EU H2020 program
  • Dipartimenti di Eccellenza Program from MIUR