We Study Molecular Recognition

Signal transduction pathways represent an accurate, complex and intricate way of transporting messages between neighboring cells. The accurate recognition of soluble, extracellular ligands by complex receptor assemblies determines multiple cellular functions by triggering or inhibiting the expression of specific target genes. It is clear that any malfunction of such a delicate, tightly regulated system would result in the re-programming of many cell functions, often with tremendous, unexpected effects.

We study these communication mechanisms by focussing on molecular recognition and regulation processes in bio-medically relevant proteins. In many cases, the proteins involved are multi-domain proteins, functioning as a unique protein machinery that carries out elementary regulatory functions such as activation, stabilization, localization and inhibition. Our goal is to reveal the mechanisms of tertiary and quaternary-induced activation in multi-domain proteins and multi-protein complexes that underlie these recognition and regulation processes.

This interview (in English) was taken in our lab in October 2014 to describe our research topics and methodologies. This is part of a series of videos created by the Armenise-Harvard Foundation - Website.

This interview (in Italian) was taken in our lab in March 2014 to illustrate our approach to the University of Pavia WebTV.