Publications

Year

Project

Type

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling.

Peng W.C., de Lau W., Madoori P.K., Forneris F., Granneman J.C., Clevers H., Gros P.

Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling.

Published in:  PLoS One, 8, e83110 (2013). - DOI 10.1371/journal.pone.0083110 - PMID 24349440

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.

Minde D.P., Radli M., Forneris F., Maurice M.M., Rüdiger S.G.

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.

Published in:  PLoS One, 8, e77257 (2013). - DOI 10.1371/journal.pone.0077257 - PMID 24130866

Complement Factor D

Forneris F., Gros P.

Complement Factor D

Published in:  Handbook of Proteolytic Enzymes, 3, 2841-2848 (2013). - DOI 10.1016/B978-0-12-382219-2.00630-X

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Peng W.C., de Lau W., Forneris F., Granneman J.C., Huch M., Clevers H., Gros P.

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Published in:  Cell Reports, 3, 1885-1892 (2013). - DOI 10.1016/j.celrep.2013.06.009 - PMID 23809763

Proteolysis, Complex Formation and Conformational Changes Drive the Complement Pathways

Gros P., Forneris F.

Proteolysis, Complex Formation and Conformational Changes Drive the Complement Pathways

Published in:  Advancing Methods for Biomolecular Crystallography, 297-307 (2013). - DOI 10.1007/978-94-007-6232-9_25

The modular serine proteases of the complement cascade.

Forneris F., Wu J., Gros P.

The modular serine proteases of the complement cascade.

Published in:  Current Opinions in Structural Biology, 22, 333-341 (2012). - DOI 10.1016/j.sbi.2012.04.001 - PMID 22560446

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Hadders M.A., Bubeck D., Roversi P., Hakobyan S., Forneris F., Morgan B.P., Pangburn M.K., Llorca O., Lea S.M., Gros P.

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

Published in:  Cell Reports, 1, 200-207 (2012). - DOI 10.1016/j.celrep.2012.02.003 - PMID 22832194

Structures of C3b in complex with factors B and D give insight into complement convertase formation.

Forneris F., Ricklin D., Wu J., Tzekou A., Wallace R.S., Lambris J.D., Gros P.

Structures of C3b in complex with factors B and D give insight into complement convertase formation.

Published in:  Science, 330, 1816-1820 (2010). - DOI 10.1126/science.1195821 - PMID 21205667

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2.

Binda C., Valente S., Romanenghi M., Pilotto S., Cirilli R., Karytinos A., Ciossani G., Botrugno O.A., Forneris F., Tardugno M., Edmondson D.E., Minucci S., Mattevi A., Mai A.

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2.

Published in:  Journal of the American Chemical Society, 132, 6827-6833 (2010). - DOI 10.1021/ja101557k - PMID 20415477