LH3 ASP529TYR
SiMPLOD ID   This is the unique identifier for this mutation in the SiMPLOD database. Please use this identifier when linking information described in SiMPLOD about this mutation.	SiMPLOD3-407
Isoenzyme   Follow the links to gather information about the LH3 isoenzyme	Lysyl Hydroxylase 3 (human) - UniProt - Full Info
Nucleotide mutation   Follow the links to explore annotated information about the significance of the PLOD3 c.1585G>T mutation	PLOD3 NM_001084.4:c.1585G>T - NCBI RefSeq NCBI SNP: rs766789252
Mutation type   Current information about the clinical implications of the mutation	SNP without clinical evidence
Evidence at protein level   Based on available structural and biochemical information, a statement about the existence of an LH enzyme variant bearing the described mutation is provided	This variant MAY EXIST at the protein level, although no experimental evidence is currently available to support its existence.
Related Entries   A list of related LH/PLOD variants found matching the structural position of the mutation currently visualized	SiMPLOD1-134: LH1 dupl326-585;TYR455THRFS (Pathogenic) SiMPLOD1-325: LH1 delta491-550 (Pathogenic) SiMPLOD1-802: LH1 ASP519ASN (SNP) SiMPLOD3-406: LH3 ASP529ASN (SNP)
Last Update   An evaluation of the possible effects/implications of the mutations on the LH3 molecular structure	2021-06-23 08:38:51
The three-dimensional visualization is currently based on the homology model of full-length, dimeric human LH3 (generated using the crystal structure of full-length human LH3 as template).
Demo Mode. Alternative PDB visualization options disabled
VIEWER INSTRUCTIONS: Use the buttons on the right-hand side of the viewer to change visualization styles, activate preset selections and save snapshots of current visualizations. Defauls colors and styles are described in Scietti et al., 2018. Mouse over on the structure to display residue identifier Mouse controls: left = rotate   on the structural model, click the left mouse button and drag the model to rotate it in the viewer    right = translate   on the structural model, click the right mouse button and drag the model to translate it in the viewer    middle = center/slab   on the structural model, click the mid mouse button to center the model in the viewer at selected residue. Click the mid mouse button and drag the model to adjust the depth-of-view according to your preferred zoom level    wheel = zoom   rotate the mouse wheel to adjust the model zoom level based on the current centered position